For instance, loss-of-function mutations in the aldosterone synthase gene (CYP11B2) can lead to reduced aldosterone levels, hypovolaemia, hypotension and shock [92 94].
For instance, loss-of-function mutations in the Arabidopsis GH28 family member At3g07970 - also known as QUARTET2 (QRT2) - result in the production of tetrad pollen, caused by the failure of the four microspores to separate following meiosis [ 84, 85].
For instance, loss of function of the G1 checkpoint cyclin dependent kinase inhibitor p21 has been linked to carcinogenesis and p21 loss is observed in 79% of colon cancer tumors by immunohistochemistry [10], [11].
For instance, loss of function of Mitofusin-2 (Mfn2) – a key protein involved in mitochondrial fusion - in cell cultures inhibits pyruvate, glucose and fatty acid oxidation and reduces mitochondrial potential [58].
To our knowledge, the results obtained in our study are the first instance of complementary function of TKL isogenes in association with stress response.
This is the case, for instance, of loss-of-function mutations of TP53, amplifications of MDM2 and MDM4, and deletions of CDKN2A, all leading to evading apoptosis and uncontrolled proliferation in malignancies such as glioblastoma.
On the one hand, he argues that there is at least one historical instance of a functioning international order that lived up to his criteria of legitimacy.
In the last few decades, many researchers emphasized expanding or generalizing the Korovkin-type hypotheses from numerous points of view in light of a few distinct angles, containing (for instance) space of functions, Banach spaces summability theory, etc. Certainly, the change of Korovkin-type hypothesis is far from being finished till today.
For instance, neomorphic gain of function mutations in isocitrate dehydrogenase (IDH1 or IDH2) results in the conversion of α-KG to 2-hydroxyglutarate, which can inhibit DNA demethylases and alter gene expression patterns (Schulze and Harris 2012).
Given the existence of an abstract function that expects data collection instructions from the site manager as input, and outputs JSON encoded measurements, additional data sources could be facilitated by implementing new instances of the function Scalability The ingestion process can be scaled horizontally by deploying additional ingestion engines across machines and networks.
