To evaluate the potential for promiscuity of inhibition, the hits presented in Figure 2 were queried against the PubChem database by noting the instances of an "active" designation versus the total number of datasets in which a particular compound is included.
For instance, stable expression of an active form of NOTCH1 (NinD1) in H446, H69, and H1688 cells inhibited cell proliferation and decreased the expression of neuroendocrine markers, such as CgA (chromogranin A), NSE (neuron-specific enolase), CGRP (calcitonin gene-related peptide), SYP (synaptophysin), and GRP (gastrin-releasing peptide) [ 10, 11].
Big Wheel (1979), for instance, was an active sculpture comprised of an enormous industrial wheel attached to an Italian motorcycle, whose attached rear wheel sent the larger metal wheel into spin.
For instance, an active extrusion of Na+ is essential for cyanobacteria in order to maintain a low, non-toxic intracellular level.
For instance, CAFs elicit an active role in the initiation, progression, metastasis and recurrence of breast tumors (Aboussekhra, 2011).
In one of the few instances in which an active player has spoken to the commissioner's office about drug use, the players union insisted that the player, Jason Giambi, be questioned only about his use and not other players'.
The chapter also discusses the significance of design of discrete filters, for instance, of passive and active elements, feedback and operational amplifiers, reactance functions, and frequency transformation in analog filtering.
Could this have been the only instance of active collaboration between the current Pope-elect and the dictatorship?
Several instances of transcriptionally active HERV loci influencing neighboring genes by providing (alternative) promoters have been documented.
We also noted rare instances of enzymes active toward galactobiose and mannobiose, with no clear correlation to their position on the phylogenetic tree (Table 1).
