For instance, it was demonstrated that shear stress affects gene expression (Paul et al. 2018), morphology and adhesion (Charrier et al. 2018; Paim et al. 2018), extracellular matrix secretion, mechanical properties, and angiogenesis ability (Charoenpanich et al. 2017; La and Tranquillo 2018; Vining and Mooney 2017) of ECs and stem cells.
For instance, it was demonstrated that CD69-/ mice display greatly prolonged tumor survival that was related to a decreased production of TGFβ.
For instance, it was demonstrated that pathway crosstalk can generate robust oscillations in calcium and cAMP concentrations [ 19].
For instance, it was demonstrated by Veridex patients that the most of highly scored patients (>90%) had good prognosis.
For instance, it was demonstrated that in KrasLSL-G12D/+ and KrasLSL-G12D/+; p53flung lung tumor models, loss of NK2 homeobox1 (Nkx2-1) [ 48] or Pten accelerated tumorigenesis [ 24].
For instance, it was demonstrated that the amplitude of a signal depends on the activity of kinases, whereas the duration of a signal depends on phosphatases 16.
For instance, it was demonstrated that stem-cell marker-negative cells were also able to grow as spheres and to give rise to very aggressively growing tumours in vivo.
For instance, it was demonstrated that LGMN co-localizes with integrins at the invading front of tumors and expression of this enzyme was shown to be associated with increased invasiveness [ 78, 79].
For instance, it was demonstrated that total levels of CI, along with abundance of CI+CIII supercomplexes, are dramatically decreased (>80%) in Arabidopsis γCA2 and γCA3 knockout lines grown in suspension culture [ 15].
For instance, it was demonstrated that the increased in vivo activation of the nuclear transcriptional regulatory factor NF-κB (but not that of NF-IL-6, cAMP-responsive element binding protein [CREB], activating protein-1 [AP-1], or serum protein-1 [Sp-1]) in alveolar macrophages from patients with ARDS is specific.
