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We did not observe a non-adaptive response with pALL8, in that for instance, depletion of tetrahydrofolate would have activated Operon 2, which contains the promoter that drives mDHFR in pALL7 but glutamin synthetase in pALL8.
For instance, depletion of RAB8B impacted Wnt signalosome activity but not other signaling pathways (Demir et al., 2013).
For instance, depletion of HOTAIR by siRNAs decreases matrix invasiveness of breast cancer cells and inhibits tumor growth of pancreatic cancer xenograft.
For instance, depletion of various nutrients, such as amino acids, phosphate, and glucose, results in nuclear accumulation of tRNAs in S. cerevisiae (Hurto et al., 2007; Whitney et al., 2007).
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But in some cases, he adds, the changes are not so slow — for instance, the depletion of fossil fuels.
In this regard, we have recently established in our laboratory all the necessary procedures for intraspecific/syngeneic spermatogonial stem cell transplantation in sexually mature tilapia, such as for instance the depletion of endogenous spermatogenesis using busulfan in association with a high temperature (35°C), isolation of tilapia spermatogonial cells and labeling of donors germ cells [11].
For instance, surfactant depletion is usually produced by saline lavage and results in decrease in lung compliance and hypoxemia [ 26].
For instance, p38α depletion, but not its specific pharmacologic inhibition, impeded cell proliferation and caused mitotic arrest, revealing p38α functions independent of its kinase activity [ 98].
For instance, PMN depletion attenuates experimental lung damage, pulmonary function in neutropenic patients with lung injury can deteriorate as neutropenia resolves [ 5], and persistent pulmonary neutrophilia in ARDS is associated with poor outcomes [ 6].
For instance, the depletion of Nup188 was shown to increase the size limit for the transport of inner nuclear membrane proteins, but this was not observed upon removal of Nup205 (the Nup192 homolog in vertebrates) (Theerthagiri et al., 2010).
For instance, plk4 depletion in zebrafish impairs centriolar biogenesis during development and increases premature cell cycle exit (independent of ciliogenesis defects) resulting in reduced zebrafish size (Martin et al., Nat Genetics, 2014).
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