For instance, compound 13c was found to be the most cytotoxic with IC50 of 4.72, 3.59, 3.65 and 4.17 μM against A-549, HeLa, Hep G2 and MCF-7 respectively, while for compound 13q, IC50 were 15.47, 5.30, 6.15 and 13.39 μM against the same cancer cells respectively.
For instance, compound 9a showed much higher activities against both G. Zeae and F. oxysporum than that of 7a, and compounds 9b-9d alshowedwed slightly better activities than these of 7b-7d.
In the first instance, compound structures are subjected to a common representation with the function StandardiseMolecules. Proteins are encoded with 8 types of amino acid and/or 13 types of full protein sequence descriptors, whereas camb enables the calculation of 905 1D physicochemical descriptors for small molecules, and 14 types of fingerprints, such as Morgan or Klekota fingerprints.
For instance, compound 3 and 12 having the same λmax i.e. 298 nm, the signal intensity of 12 is one of the highest in both cases of bradykinin and renin substrate tetra-decapeptide, while, intensity levels of compound 3 are among the lowest.
For instance, compound 5 was induced bradycardia, however great increasing in the heart rate showed by 6, whereas abolished in the tachycardia term and slightly induction on bradycardia was demonstrated by 7. Similarly, transformation of 4 into 9 has emerged more bradycardia effect accomplished by moderate decreasing on blood pressure.
For instance, compound 1a13, which promotes efflux effectively, is structurally-related to 1a5, 1a6, 1a7 and 1a8.
Few of these analogs for instance, compounds 6, 7 and 8 are shown to be more effective than recent Selective Estrogen Receptor Modulators (SERMs) i.e. Ospemifene and Tamoxifen, against these cell lines.
For instance, compounds from "Hemostatic, stasis resolving" showed wound healing activity, which can be suggested from the action of compounds against PTPN2 [1,2] and the mineral absorption pathway [3].
For instance, compounds liquiritin and licochalcone G can destroy bacteria by targeting the metalloelastase and strengthen the tissue macrophages to defense against external invasions.
For instance, compounds 8n, 8k, 8' l' and 8m, which contain aliphatic side chain with 17, 18, 19 and 20 carbons, respectively, inhibited the growth of M. smegmatis with MIC values of 8, 16, 64 and 128 mg/L, respectively.
For instance, compounds that require long exposure time or show a tendency to adsorb to the apparatus may require lengthened preincubation times and multiple applications at the expense of decreasing the number of data points that can be acquired per day.
