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For instance, altered processing of the cyclin E RNA produced different isoforms of the protein with different affinities for Cdk2 [52], [53], [53].
Once in the tumor, E. coli for instance altered the tumor microenvironment in murine breast tumors by vascular remodeling, focal concentration of tumor associated macrophages and focal expression of MMP-9 and TNF-α around bacterial colonies [27].
For instance, altered dlx-2a, fgfr1 and axial expression could only be observed in 17/30, 11/30 and 3/30 fmorphantsants, respectively; for neurite branching phenotypes no numbers are given related to the penetrance of the defect; injection of antibodies against alpha-acetylated tubulin resulted in a dramatic axon defect only in 3/30 and axon defasciculation in 13/30 fmr1 morphants.
For instance, altered cell proliferation and/or motility were observed upon down-regulation of members of the MAGE-family in mast cells or multiple myeloma cells and SSX in mesenchymal stem cells or by ectopic overexpression of CAGE in fibroblasts [ 21- 24].
For instance, altered brain activation during attention allocation and motor response inhibition tasks has been observed in VPT adolescents (Nosarti et al., 2006) and adults (Lawrence et al., 2009), which may reflect a differential engagement of task-specific brain areas, as well as the use of alternative neuroanatomical substrates for task completion.
In the first instance, altered levels of NMT expression in transgenic parasites were confirmed by Western blot, using TcTryR as a loading control.
Similar(53)
Work in social genomics reveals that our personal histories of social connection or loneliness, for instance, alter how our genes are expressed within the cells of our immune system.
Jolla's smart covers incorporate NFC so they can tie in with the software on the phone — meaning when a particular Other Half is put onto the handset it can change the look and feel of the software — by, for instance, altering theme colours and graphics.
For instance, altering the targeting subunit of the phosphatase PP1 leads to either an obese insulin resistant phenotype [53] or a normal phenotype depending on the donor background [54] even though both studies backcrossed onto the C57Bl/6 line.
These candidate effectors could, for instance, alter the temporal distribution of sleep bouts without changing the overall daily sleep amount.
Protein denaturation at 6°C might not be severe enough to compromise protein function directly, for instance altering enzymatic activity, but it likely represents a stress signal for UPR.
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