The experience of reading California brings validation to anyone who sits upright in the middle of the night struck with the instability of the human project on this planet: others are awake, too.
In fact, as long as the most exiting scientific ideas are tested with the highest quality in orthopaedic research, one will eventually be able to see the bigger picture in these enigmatic instability patterns of the human knee.
We have not only developed a new powerful method to diagnose GAN, we have also provided the first evidence that disease-associated mutations confer instability of Gigaxonin in the human pathology.
"The changes in the environment that we see as adverse – from rising carbon dioxide abundance, climate change and population growth – are," he writes, "all consequences of this new [evolutionary] inflation; as may be economic instability and the tendency of the human species to become city or nest animals".
"Who may pause to peruse this tale of sorrows let this awful lesson of the instability of human happiness sink into thy mind," the monument warns, in English and Italian.
However, recent studies have also uncovered an epigenetic instability of the X chromosome in human iPSCs that warrants careful consideration.
Also outstanding are poems expressing love for his children and laments on the death of his son, on the instability of human life, and on his own sickness and old age.
Our studies, combined with others [ 42], have yielded a predicted timeline of genomic events affecting human chromosome loci 4p16 and 8p23 that have contributed to the structural complexity and genomic instability of the OTOP1 locus in humans; this timeline highlights interesting evolutionary parallels between these two regions.
Even after establishing himself in Hollywood and expanding his range of subjects, he remained a master of ambiguity: his films were obsessed with the variety and instability of human behavior and the conflicting interpretations to which it gives rise.
