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Instability in the full-length construct could also explain why alpha-satellite consensus sequence (through which the cenRNA was cloned) are lacking in the 665bp.
This initial amplification event may induce instability along the length of this chromosomal arm, resulting in co-amplification of other genes.
Additionally, after accounting for constitutive repeat length, somatic instability in the human cortex has recently been shown to be a significant predictor of HD onset with larger repeat length gains associated with earlier disease onset (3).
To clarify the effect of oxidative stress on chondrocyte telomeric instability in the cartilage, we analyzed the telomere length of chondrocytes that were isolated from cartilage explants cultured in the presence of an antioxidative agent (Asc2P) or ROS (H2O2) in vitro.
The main difficulties lie in the length of the GAA expansion needed to induce pathogenesis and the locus of genomic integration, as well as the intrinsic GAA instability that can result in contraction or elongation of the expansion.
So: continuing instability in the world.
"It is the source of instability in the region".
Instability in the regime might worsen the nuclear crisis.
Anonymous, 36, London There is growing instability in the World.
"I had a pinched nerve and instability in the shoulder".
Increased instability in the Middle East is another factor.
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