Thus, exceptional hermaphrodites in willows are likely to originate from the initial breakdown of the dioecious system or developmental instability in sex expression.
Thus, to fully understand how insertion site might contribute to phenotypic outcomes, to more cost effectively manage transgenic strains and to fully understand instability in transgene expression, routine identification of transgene insertion sites is desirable.
To obtain a complete understanding of how insertion sites might contribute to phenotypic outcomes, to more cost effectively manage transgenic strains, and to fully understand mechanisms of instability in transgene expression, we've developed methodology and a scoring scheme for transgene insertion site discovery using high throughput sequencing data.
In this case variation of the ratios of two candidate reference genes reflects instability in expression levels of one gene.
However, high clone to clone variations as well as instability in expression levels have been found.
- Since VPA causes DNA instability in tumor cells,,, expression of a wild-type TP53 in LNCaP cells may make them more sensitive than the other two cell lines.
However, expression levels typically diminish with virus passage because of instability in the region of the genome containing the duplicated promoter and heterologous sequence [3], [4].
Specifically, we study for the first time genome-wide repeat instability in the promoters and exons of 18,439 genes, and examine the association of repeat instability with genome-scale gene expression levels.
These instabilities depend on the expression of the delay function (and the connectivity function as well).
