The initial model was improved by visual inspection and model building with COOT [52].
Each cycle of refinement consisted of electron and difference density map inspection and model manipulation together with incorporation of cofactors, waters and ions, followed by REFMAC5 refinement.
Data inspection and model simplification showed that Thai/8+8 type infections had a significantly higher sex ratio (χ1 = 10.7, P = 0.001) than SL/4+4 types and both types responded similarly to haematocrit (χ1 = 17.7, P < 0.001) (Fig. 4).
Data inspection and model simplification regrouping the treatments into single vs. mixed clone infections revealed that mixed clone infections resulted in greater anaemia for a given parasite density (Parasite density χ1 = 52.8, P < 0.001; mixed vs. single clone infections χ1 = 6.8, P = 0.009).
His software uses sophisticated packet inspection and statistical modeling techniques to take snapshots of what moves across the continually changing network of PCs.
This involved first a rigid body refinement as part of the molecular replacement calculations, then iterative cycles of restrained refinement combining REFMAC5 [ 18] with electron and difference density map inspections, and model manipulations in COOT [ 19].
Finally, an extensive catalogue of inspection and maintenance models under gamma-process deterioration is presented with the emphasis on engineering applications.
Three variable selection strategies based on visual inspections and regression modelling were also evaluated.
A multidisciplinary approach, with a balanced fusion of historical analysis, precision surveys, experimental inspections and numerical modelling, enabled to spot the damage mechanisms that have provoked the first disorders and the ones that are still active, giving hints on the possible solutions.
These steps involve the fabrication of the 3D printed model and subsequently the inspection and utilization of the model for patient care.
