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In addition, Φ-values and ΔΔGU-‡ reveal striking similarities in the TS of Raf RBD and ubiquitin, a structural analogue displaying insignificant sequence identity (<12%).
Additionally, cross-reactivity between related protein families with similar folding but insignificant sequence homology could be detected by this approach [5].
The contributions of specific residues to the delicate balance between function, stability and folding rates could be determined, in part comparing the sequences of structures having identical folds, but insignificant sequence homology.
The similarities in overall structure and spatial organization of functional domains in ERev and FIV Rev occurred despite the fact that they share insignificant sequence similarity (BLAST alignment E-value = 6.4).
Comparison of the structure of the MC sequence region in a homology-based Ago2 model to that of the cap-binding motif in eIF4E reveals some very localized structural similarities captured as statistically insignificant sequence similarities by BLAST.
In particular, the first and second α helices of the LSD1 SWIRM domain spanning residues 172 to 196 show insignificant sequence and structural homology to the closest human SWIRM domain-containing proteins, providing an ideal platform for the selective targeting of LSD1.
Similar(53)
In opposition, the intraslab events (and crustal shocks above the subduction zone) on the west side of the Cascades have had insignificant aftershock sequences, usually amounting to a minimal number of small aftershocks.
This result predicts that a smaller, but not insignificant, amount of sequence data could be obtained from the rest of Apocynaceae.
This ensures that the random factor due to the meeting sequence remains insignificant for various values of (gamma) and (beta).
On performing One-way ANOVA it was found that the variation between the results (in percentage) of real time PCR and shotgun sequencing was insignificant for all bacterial species except for the Prevotella bryantii population.
Nevertheless, when the dinucluetide frequencies were fixed, the energies of the permuted controls were similar to those of the native sequences, suggesting insignificant nucleotide-order effect with fixed dinucleotides frequencies.
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