The low BMI of patients (Group I; mean BMI = 23.2 kg/m and Group II; mean BMI = 22.4 kg/m) in our study population might account for the insignificant association between DN progression and variables for metabolic syndrome.
MRI (one cohort, two cross-sectional, one case control study): one prospective, well-adjusted, but below-average-quality cohort analysis found an association with baseline attrition severity and structural progression that became insignificant after covariate adjustment [ 82].
An increase of 10 µg/m3 in the home outdoor PM2.5 concentration was associated with a statistically insignificant 1.74 and 2.53 µm/year faster progression in CIMT in the unadjusted and the main adjusted model, respectively (Figure 1).
Men who have only clinically insignificant disease have little to no chance of disease progression within their lifetime, and some have proposed they would have no certain benefit in being treated with active therapies [110].
Progressive addition lenses (PALs) have shown insignificant effect on myopia control, 6 11 and bifocal spectacle lenses have shown promising effect on children with fast myopia progression.
It is important because such subclinical inflammation may lead to progression of atherosclerosis and the destabilisation of haemodynamically insignificant atherosclerotic plaques, causing development of new vascular events.
This result indicates that the effect of hepatic functional reserve on tumor progression of patients treated with sorafenib may be insignificant.
Similar statistically insignificant results were obtained between PAIP2 levels and patient's progression-free survival (P=0.80) or overall survival (P=0.59) (data not shown).
A minor but not insignificant proportion of patients (30%) [ 4, 5] have a high risk of progression with a severe worsening of the prognosis and therapeutic options [ 6].
In the third instance, the targeted agent results in minimal or insignificant suppression of the tumour vascular supply, resulting in stabilisation of disease or tumour progression (Fig. 3c) [ 121– 121].
