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Non-correlated expression and localisation of different epitopes suggested insignificant expression of full-length (FL) BARD1.
These tests revealed high, medium and insignificant expression of miR-608, validated by sequencing in human intestine, brain and white blood cells (Fig. 1D and Supplementary Material, Fig. S1B).
Although insignificant expression of Sox17 was observed in IOD embryos exposed to 4-OHT for 24 hours from the 8-cell stage (Fig. 2D), the number of Sox17-positive cells could be restored to normal by provision of FGF2 or FGF4 (Fig. 3A,B).
Nonetheless, largely impaired activities of FOXP3+ and CD4+ cells along with insignificant expression of CTLA4 mRNA in CE biopsies could suggest that underlying mechanisms, by which the parasite mediates the long-lasting suppression of immune responses in the human liver, are probably T cell-independent.
Insignificant expression of CD28 and CTLA4 mRNA measured in this study could suggest the poor activity of T cell-dependent mechanisms at the periphery of hydatid cyst in human chronic infection, probably due to the clonal deletion of specifically activated T cells [ 36].
Furthermore, in different solid tumours, variable MMP-2 protein amounts with insignificant expression of MMP-2 mRNA have been shown and correlated to feedback mechanisms, being able to shut off messenger expression after the secretion and/or binding of the protein [ 32].
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(iv) Discretization avoids the effect of insignificant expression difference in bi-clustering algorithms, and at the same time, enables mining a complete set of patterns efficiently rather than heuristic detections in bi-clustering algorithms.
This non-cyclic fraction increased only slightly to 80.8% for the entire set of 7,784 genes, reflecting the generally low or insignificant expression levels found for most of the 4,951 Toxoplasma genes that were excluded from the cyclic set by our stringent criteria.
Furthermore, these CBF genes, as well as the homologues of CBF constitutive activator ICE [ 47],[ 48], had insignificant expression variation in chilling treatments partly due to their low expression levels.
The discretization used here is able to eliminate insignificant expression difference in M. Note that there is no gold standard to determine the optimal number of discretization items.
The absence of typical phytoplasma leaf symptoms in the second growing season was correlated with an insignificant differential expression of genes encoding sucrose synthase, callose synthase and 1,3-β-glucanse gene VvGlc3.
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