"The changes have really been insignificant," he said.
When the Square Hebrew alphabet became standardized, it took (at least, in its formal style and, much later, in its printed form) the form that, with insignificant changes, it has today.
But cultural and economic changes have diluted that power and left many men feeling insignificant and angry (if not downright obsolete).
While the proposals were not insignificant, earlier efforts at change have faltered because of an entrenched bureaucracy and the Kremlin's unwillingness to dilute its power by making the police more independent and providing rigorous oversight.
And (3) the impacts of land-use change have shown insignificant effect due to soil conservation measures, whereas the impacts of rural residential area account for great proportion changes, of which about 5% of its increases are contributed to the increase of livestock and poultry breeding; but the biggest contribution rate is still from the output of different land use types.
Based on energy distribution analysis, when a catalyst was used, sensible heat decreased while the heat of desorption and heat of vaporization had insignificant changes.
Repair frequency has insignificant changes with decreasing COV but the trend of cost function changes to similar trend from deterministic method since the minimized COV yields deterministic results.
The other genes had insignificant changes in expression level (data not shown).
As a control, house-keeping gene TBP (TATA box binding protein, accession number NM_003194) expression level had insignificant changes over the course of the culture, and the variation probably reflects the range of error of the assay.
Two further tight junction genes showed significant downregulation (JAM3 1.3 fold decrease, p = 0.004 and CLDN15 2.0 fold decrease, p = 0.015), three others had insignificant changes (TJP1 1.2 fold decrease, p = 0.154; TJP2 1.1 fold increase, p = 0.054 and CLDN22 1.1 fold, p = 0.74), while 17 showed negligible expression in both cell lines (Additional file 4: Table S2).
