Genes with increase expression in respond to both FW and SW transfer at 1 h and/or 3 h while insignificant changes at other time points were considered as stress-related.
Immediately before this expansion, there is a small drop in effective population size ∼17 16 kya (this is an insignificant change, as judged by the overlap in 95% confidence intervals at the beginning and end of the population decrease), possibly corresponding to a population bottleneck prior to entry to the Americas.
The positive effect of etanercept is evident from the 24% reduction of PMR-AS in patients treated with the drug, as well as the insignificant changes in PMR-AS observed in placebo-treated patients.
Both HYP and CONN characteristics showed statistically insignificant change at p ≤ 0.10.
After 16 weeks of exenatide therapy in patients with type 2 diabetes, patients with the metabolic syndrome experienced significant reductions in TC (-7.4 mg/dL, p < 0.001), TGs (-16.7 mg/dL, p < 0.001), SBP (-2.6 mmHg, p < 0.01), and DBP (-1.2 mmHg, p < 0.03), as well as insignificant changes in LDL-C (-2.8 mg/dL) and HDL-C (-1.4 mg/dL) [ 67].
In Table 4, the two genes, Calcr and Adh7, were detected by all other four methods, except DESeq for Adh7 (p-value = 0.06), whereas XBSeq tested on the true expression signals and considered them as insignificant changes (p-value = 1 and 0.53, respectively).
However, considering the median as a threshold for a general purpose texture description might not be useful in many cases, because median cannot guarantee the proper separation of significant and insignificant changes since it is determined as the midpoint of data.
Test/retest reliability measures the stability of a measure over a short time period, i.e. determines whether a measure is sensitive to change but not so sensitive as to report clinically insignificant changes.
AMD was graded as 0 (no changes), 1 (insignificant changes) or 2 (mild changes), and the grade from the least affected eye was used for analysis.
Nevertheless, the fact that all of these insignificant changes were upward was, itself, statistically significant.
