Though it is possible that it may show invariably poor membrane permeation properties in vivo, such drugs will undergo insignificant transport through the brain capillary endothelium, which makes up the blood brain barrier (BBB) in vivo [ 4].
The power of Data's positronic brain is insignificant next to the power of the Force.
Residual functions detected in brain death are insignificant functions.
CH4987655 exhibits slow dissociation from the MEK enzyme, remarkable in vivo antitumor efficacy both in mono- and combination therapy, desirable metabolic stability, and insignificant MEK inhibition in mouse brain, implying few CNS-related side effects in human.
The restrictions on connection directions are not an insignificant design feature of the brain, considering the possible connections among nodes in three-dimensional space.
Besides poor membrane permeation properties, insignificant transport occurs through the brain capillary endothelium affecting the drug availability in theoretically relevant concentration [ 8].
Layer II/III neurons were found specifically reduced in both Nde1−/− and Nde1+/− Lis1+/− mice, and they were abolished almost completely in Nde1−/−Lis1+/− mice along with severe brain hypoplasia but insignificant change in the body size (Feng and Walsh, 2004; Pawlisz et al., 2008).
Apparently, the male and female brains handle an insignificant stimulus like noise differently, and we speculate that this is done by a different engagement of the auditory prefrontal attention network.
Season seven of Game of Thrones premieres on Sunday, July 17.
At baseline, sex differences in the brain can sometimes be small or insignificant but are often revealed or exacerbated following stress, injury, disease, or treatment with a drug.
With 95.8 % of paired temperature readings within 2SD (−0.4 to 0.4 °C) differences in temperature between brain tissue and ventricle were clinically insignificant.
