Seeing all that information, does that make patients more informed and active partners in their care, or does it make them feel more worried about a slight and insignificant abnormality"?
Thirty-eight candidate variables collected at baseline, consisting of demographics, clinical measurements, medical history, investigator reported ECG (normal, clinically insignificant abnormality or clinically significant abnormality) and laboratory results, were included (listed in table 1).
People with only one abnormal gene are called carriers (heterozygotes) and may have mild, but medically insignificant, abnormalities of copper metabolism.
The reporting radiologist may not know enough to identify or recognise the relevant finding (or to correctly dismiss insignificant abnormalities).
Insignificant abnormalities were found in 33 patients: paranasal sinus thickening (13), septum pellucidum cyst (2), pineal cyst (3), arachnoid cyst (3), circle of Willis variants (6), signs of chronic cerebral ischemia (5), doubtful small subependymoma (1).
Additional inclusion criteria included clinical laboratory test results within normal limits or with clinically insignificant abnormalities, negative illicit drug and alcohol screening tests, and if appropriate, negative urine pregnancy test, documented bilateral oophorectomy and/or hysterectomy, or postmenopausal status with cessation of menstruation for >2 years.
The highest number of AEs was in period 5 (800 mg bid) and the fewest in period 4 (600 mg bid); gastric AEs, including transient nausea, flatulence, and loose stools, were more prevalent at 800 mg bid, clinically insignificant biochemical abnormalities at 400 mg bid, and cardiac AEs (transient palpitations) while taking 200 mg bid of ATI-2042.
Lumbar spine MRI may reveal either clinically insignificant spine incidental abnormalities and/or extra-spinal IF that, at times, may even explain the patient's symptoms.
The mean MCD between the patient and control groups of the three muscles showed a statistically significant difference in the APB muscle only, while those of the ADM and EDC muscles were insignificant, which localizes the abnormality to the APB muscle.
As part of the questionnaire, patients were asked to rate their individual taste and smell abnormalities as "insignificant," "mild," "moderate," "severe," or "incapacitating".
In addition, the analyzed sperm shape abnormalities were also found to be insignificant to that of sperm shape abnormalities in the control group indicating that BR is not inducing reproductive toxicity in the mice (Table 2).
