These results contribute new insights to answering the fundamental question on how mammalian cells respond to d-amino acids or d-peptides (e.g., containing aromatic group(s) as the self-assembly promoter) when the self-assembly of the d-peptides integrates with endogenous enzymatic reactions.
Therefore, this report not only illustrates a new way for tailoring the properties of supramolecular assemblies, but also provides new insights to answering the fundamental question of how mammalian cells respond to enzymatic formation of nanoscale supramolecular assemblies (e.g., nanofibers) of d-peptides.
We analyze the factors that can impact antidrug antibody (ADA) responses and their correlations with preclinical and clinical outcomes to provide relevant insights and to answer questions, including what types of aggregate are immunogenic.
We do so with the aim of contributing new insights to theory through answering the following research questions: What strategies to tackle wicked environmental problems are prominent in the literature?; To what extent do they provide pathways for tackling the defining characteristics of wicked environmental problems?; and, How are these strategies reflected in examples of practice?
When working with policymakers to craft legislation, be proactive in offering your ideas or insights; be prepared to answer questions; and present solutions and a rationale to support those solutions.
"He recognizes the kernels of the unknown in them," the citation said, "surrounds them with the known, and searches through this mechanism for insight in how to answer the questions that exist".
That deeper insight is needed to answer important questions.
"Strong-armed regulation," said the new nudge unit, in applying behavioural insights to health, "is not the answer to rebalancing our diets, changing our desire to drink too much alcohol on a Friday night or making our lives more active".
Despite these limitations, this study will provide additional answers and insights to further develop, refine, test, and disseminate effective, low-cost behavioral interventions that improve HRQL in the older patients with multiple comorbidities who live in remote areas.
We obtain topological insights on CTP performance, to answer the question: Which topological patterns cause CTP data routing to fail?
