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To get insights on the constraints shaping the evolution of SS1G_07749 xylanase, we predicted the 3D structure of SS1G_07749 mature protein and mapped the local Ka/Ks ratios on this structure.
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Design researchers are also able to build innovative designs, prototyping the design artifacts of the future to gain insights on the issues, constraints and opportunities which designers will face in years to come.
In addition to this, we provide insight on the fundamental constraints of the considered problem.
Studies that examine the evolution of splicing-associated regions, especially exon-intron splicing junctions and ESEs, have provided much insight on the selective constraint associated with splicing.
Wood cellular parameters varied in response to seasonal climate, providing insights on the mechanisms of tree-ring formation, and reflecting physiological adjustments to environmental constraints.
Such data will lead to insights on the radiogenic heat production in the Earth, the composition of the mantle, and constraints on the chondritic building blocks that made the planet.
Numerous applications of these models demonstrated the power of constraint-based modeling in general and gained invaluable insights on the metabolism of E. coli [ 2].
The reduced model described above is simple enough to gain a clear insight on the impact of the solvent capacity constraint on metabolism.
Our results provide important insights into the functional constraints on intracellular transport under which cells have evolved cytoskeletal structures, and have potential applications for enhancing reactions in biomimetic systems through rational transport network design.
Furthermore, the ability to correctly model Ks variability across sites may reveal novel insights into the functional constraints acting on the DNA and RNA levels, which cannot be inferred using standard codon models.
Insight on the News 10: 29–310
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