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Insights into the constraints of the PfDXR binding site provide additional scope for the rational design of DXR inhibitors with increased ligand receptor interactions.
Recreating fossil receptors for functional studies in the laboratory can provide important insights into the constraints that shaped molecular structure and function in this diverse superfamily that are difficult to attain by using more traditional mutagenesis methods.
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Qualitative design was followed to gain a more in-depth insight into the constraints in the PEI perceived by health workers and managers in a district.
Such accounts of CHW motivation suggest that understanding the influence of community context and culture beyond individual cognitions is critical when seeking insight into the constraints and facilitators of CHW motivation and the key to developing effective, context-specific strategies [ 4, 9, 10, 21, 41].
The power of the transient transfection assays has allowed thorough dissection of numerous cis-regulatory modules, which provided insights into the functional constraints that shape enhancer architecture and diversification.
Our results provide important insights into the functional constraints on intracellular transport under which cells have evolved cytoskeletal structures, and have potential applications for enhancing reactions in biomimetic systems through rational transport network design.
This is logically therefore the next challenge, and may offer insights into the real constraints of different mechanisms.
Insights into the structural constraints of the interaction sites might allow the design of pharmacological inhibitors of these interactions, opening opportunities for targeted therapeutic interventions in the future.
Furthermore, the ability to correctly model Ks variability across sites may reveal novel insights into the functional constraints acting on the DNA and RNA levels, which cannot be inferred using standard codon models.
Testing this evolutionary hypothesis would require to gain insights into the selective constraints (e.g. the selective pressures acting on the different phenotypic traits), the interaction between selection and migration (e.g. the fitness of the various classes of crop-weed hybrids) and into the genetic architecture of phenology and of the presumably selected traits.
To provide further insights into the evolutionary constraint acting on CSSs, we examined the frequency distribution of the SNPs.
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