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These models are used to analyze patient-derived data and thereby gain mechanistic insights in the processes underlying drug pharmacokinetics (PK).
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The results provide unexpected insights in the process which contains distillations in which complex reactions occur.
The authors re-examine some of these findings, providing useful new insights in the process.
To provide the first insights in the process of BMPEA excretion, four real case samples were used to investigate the influence of hydrolysis of phase II metabolic conjugates on method performance.
Although studies using mouse ES cells have provided key insights in the process, important questions still remain, and novel genes are continuously being discovered (reviewed in Barakat et al. 2010; Chaumeil et al. 2002; Navarro and Avner 2009, 2010).
These findings increase our insight in the processes leading to reduced performance at work, and suggest that organizations should facilitate opportunities for recovery.
To gain more insight in the processes underlying cold-induced mitochondrial uncoupling, further research is needed to unravel the molecular nature of these processes in human skeletal muscle.
To gain molecular insight in the processes governing the malignant transformation of hepatocytes in DKO animals, we determined the activation of the major stress-dependent MAPK-signaling pathways.
Time-resolved fluorescence measurements play a key role in gaining further insight in the processes behind the change of the radiative emission rate of the fluorophores.
Another molecular level that could provide additional insight in the processes of aging is the epigenome, the intermediate layer of genomic information between the genome and transcriptome.
To gain insight in the processes associated to the onset of woolliness, we have investigated the transcriptional behavior of genes known to be involved in cell wall metabolism and hormonal regulation by gene set enrichment analyses (GSEA).
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