This work identifies insightful structure-property relationships for CO2 activation and highlights the importance of keeping a balance between NP stability and CO2 adsorption behavior in designing catalytic bimetallic NPs that activate CO2.
The most functionally insightful structural information comes from the crystal structure of the full-length beetle Tribolium castaneum TERT in complex with a short DNA RNA helix [ 34].
Although EM 2D classes give insightful information on the structure of AcrB, a 3D reconstruction was also generated to obtain further structural detail.
All these methods describe signal flow qualitatively within a mathematical formalism and without loss of information on the network topology, allowing insightful computations on network structure such as evaluating the degree of cross talk, determining all possible elementary 'flux' modes and calculating the number of theoretically possible positive and negative feedback loops.
Structural characterization of aaRS functions in both categories has deepened our understanding and provided insightful platform for further structure-based drug design.
The methodology could be extended to other P450 systems, is faster, and comparably insightful as more elaborate structure-guided approaches such as X-crystallography.
Molecular modeling and simulation has been recognized as an effective tool for gaining a comprehensive and insightful understanding of nanomaterial structure-property relationships, which are critical for nanomaterial development.
2) Both articles: both structures used insightful methods to accomplish crystallization – fusion to a coiled coil protein and ligation between two proteins, respectively.
T he landmark discovery of DNA as the hereditary material by Avery et al. in 1944, followed by the insightful report on the helical structure of DNA, paved the way for our current understanding and use of nucleic acids, including the development of oligonucleotide (ON) therapies.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1472-6963/10/133/prepub We thank Drs. Thomas C. Buchmueller and David Frisvold for their valuable comments on the methods of the study, and Dr. Edward Gregg on his insightful comments on the overall structure of the manuscript.
Visualization presents an insightful display of the motif structures, thereby providing the research community with a graphical understanding of the nature of association between the miRNAs and diseases.
