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Further work is needed to understand how T3SS translocon insertion results in caspase-1 activation.
Heterozygous mutation of Drosophila OPA1 (dOpa1) by P-element insertion results in no obvious morphological abnormalities, whereas homozygous mutation is embryonic lethal.
Disruption of the PTE by P element insertion results in a loss of enhancer-directed Abd-B expression during embryonic development and a homeotic transformation of abdominal segments.
While such insertion results in a mild attenuation of VSV [23] and SeV [24], [27], both viruses replicate similarly to parental wt strains (data not shown) and, thus, serve as useful models for studying replication of wt viruses.
The insertion results in addition of a methionine residue in gL that may potentially serve as an alternative start site.
The insertion results in a frameshift in the first exon, introducing a premature stop codon four amino acids downstream the insertion.
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In the SCH cell line, AGG was inserted between codon 249 and 250; this insertion resulted in an abnormal structure of the p53 protein.
In two different trials, vector insertion resulted in the transcriptional activation of proto-oncogenes.
The nucleotide changes consisted of an insertion, resulting in a frameshift mutation, and missense mutations of highly conserved residues.
Fluorinated MWCNT insertion resulted in an increase of nanofibrils amount due to a filler nucleation ability increase.
To evaluate whether home visits for contraceptive implant insertion result in an increase in postpartum uptake compared to clinic insertion and to assess the feasibility of home insertions.
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