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Factors associated with its development include IVH, insertion outside the operating theatre and EVD placement days.
There is one clear-cut example of cassette insertion outside an integron emerging from the analysis of the DAT722 array.
In gun4-II the plasmid insertion outside the GUN4 gene has caused a genetic rearrangement of the GUN4 gene that prevented gene expression.
The latter scenario of cassette insertion outside an integron context has been previously documented for gene cassettes generally associated with class 1 integrons [ 3].
Given the location of this insertion, outside of the proofreading NTD, we surmise that it either disrupts the ability of ε to bind to α or results in an unstable protein.
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Of the 1,471 fly lines for which coordinates were available, 546 are insertions entirely outside gene regions and of the 925 remaining lines that do insert within a gene model, only 449 are found in introns between coding exons.
The remaining 13 fluorescent proteins resulted from insertions outside the Prestin coding sequence, most of them being clustered just downstream of the CMV promoter.
This has inhibited progress in understanding retrotransposon insertion dynamics outside of a few well-studied species.
The enrichment of miRNAs loci in proximity to CIS inserts is higher than the enrichment of miRNAs around non-clustered retroviral insertions located outside of CISs.
Moreover, one-third was inserted outside the ICU, chlorhexidine preparation of the site was only used in less than 10% of insertions, and AST-CVCs were not used.
Because the three localized insertions were outside the known inversions and not in the "islands of speciation", these sites could result simply from genetic drift that has occurred after the separation of the M and S forms.
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