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Such a preferred orientation prompted us to propose a "propeller" mechanism for SNAREs, in which synaptotagmin binding and membrane insertion drive SNARE complex to laterally turn over by 180°, causing SNARE TMDs to disrupt lipid bilayer structures.
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The majority (52.2%) of those initiating IUDs were married, which was predictive of uptake over never-married women (adjusted relative risk 1.52, CI 1.44-1.59, P<.AmongAmong servicewomen, we observed low but rising rates of LARC insertion, driven by increasing implant use.
Both elav-GAL4 insertions drive expression of UAS constructs throughout the central and peripheral nervous system.
The limitations imposed by the read length for detecting large insertions drove us to define a separate strategy.
Like the mutations in human cancer, tumour DNA will contain both insertions that drive oncogenesis (oncogenic insertions) and insertions that are passengers (background insertions).
We examined the pattern of expression of C32 by using the C32-Gal4 insertoon to drive expression of UAS-GFP.
The dilp levels in adult heads of nine independent insertion lines driven by d2GAL were analysed by RT-QPCR.
Cno expression was examined in embryos that carry a twi-CD2 insertion, which drives the expression of the transmembrane protein CD2 under the control of a mesoderm-specific twist (twi) promoter.
(3) 80% of the post-divergence insertions were driven by 20% of highly active families (Table S6).
Functional constraints are probably more relaxed in these regions, and the observed evolution of insertions is driven by unknown mutational mechanisms, which might tend to produce similar motifs by homoplasy [ 59].
Finally, activating DA VTA neurons optogenetically is sufficient to drive insertion of GluA2-lacking AMPARs, mimicking the changes observed after a single injection of morphine, nicotine or cocaine.
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