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The inserted side chain points directly toward the active site, where its negative charge may impede binding of β-lactams via repulsion against hydrophobic regions of the antibiotic or more simply alters the acylation chemistry that results in opening of the β-lactam ring by perturbing the electrostatic balance around the serine nucleophile.
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As a result, the gene cassettes are inserted side-by-side in a single chromosomal locus.
Supportive of this inward orientation of T-RTi is the adjacent change of Ser-195 to glycine in mtRF1, most likely to accommodate the inserted threonine side chain.
A few large-leaved species of succulents can even be grown from partial leaf cuttings:[22] Streptocarpus species can have the leaves cut in half lengthwise, discarding the central rib, and inserted cut side down into a shallow trench.
In Europe, the boxes have a triangle at the bottom corner of the paper sleeve-insert side.
Insert side gear into differential case.
The increased affinity of RADH-G37D for NAD(H) depends on an interaction between the adenosine ribose moiety of NAD and the inserted aspartate side-chain.
The new compounds present a methoxy (3), a hydroxy (4) or a dimethylaminopropoxy (5) side chain inserted in position 8 of the lead chromophore.
Unnatural amino acid residues, with longer side chains, inserted at position 288 were autophosphorylated and supported substrate phosphorylation.
In this work, the structure of the channel was explored by inserting large side chain residues at four positions along the channel in BjPutA.
Now that you have your battery, insert it into your device's battery bay by inserting the side with the gold terminals first.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com