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The 5-bp sequence CTCCG is a typical target site duplication (TSD) sequence for a retrotransposable element (retrotransposon) to insert in a new site of the genome (Han et al. 2010).
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DNA transposition is the process by which a special segment of DNA embedded in a chromosome is excised from one site and inserted in a new location.
In germinal cells, Mu transposition uses a "replicate-and-insert" mechanism where the element replicates just before meiosis or in the gametophytes and inserts in a new locus in the genome.
Four tissue cores (0.6 μm diameter each, 3 tumoral and 1 normal control) were sampled from each block to account for tumor heterogeneity and inserted in a new receiver block.
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To be deleted here and inserted in a new Rule 11b.
To be deleted here and inserted in a new Rule 11a(5).
To be deleted here and inserted in a new Rule 11a(2).
The Alu region is then reverse-transcribed and inserted into a new location in the genome [ 24].
A few repeats may excise from a tandem array and circularize to provide a template for rolling circle replication [72], and after amplification into a linear array, the repeats may be inserted into a new location in the genome.
However, when a non-LTR retrotransposon inserts itself in a new location in a genome, the 5′-end of the sequence can be lost due to incomplete reverse transcription (Gilbert et al. 2002).
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