You really are a vile, insensitive human aren't you, @rupertmurdoch?
Specifically, in the androgen insensitive human CaP line PC-3, 24 h calcitriol pre-treatment yielded a 36% increase in cell death at the −15 °C isotherm compared to temperature-matched controls (60% viable vs. 96%, respectively).
I spent many of my weekends watching birds on the Tees Estuary in the early 1970s, and the air there smelled bad enough to my insensitive human nose.
Serum-free media conditioned by the androgen insensitive human prostate cancer cell line DU145 showed immunological transforming growth factor-alpha (TGF alpha) activity, as well as competing activity in epidermal growth factor (EGF) radioreceptor assays (RRA).
To address the role of the cysteine-rich loop in NF449 and suramin action, we generated a series of deletion mutants and chimeric receptors where portions of the cysteine-rich loop region of the human P2X1 receptor were replaced by the corresponding regions from the insensitive human P2X2 receptor.
The WST-1 cell proliferation assay was employed to assess their anti-proliferative effects toward both androgen-sensitive and androgen-insensitive human prostate cancer cell lines.
Gupta, S., Ahmad, N., Nieminen, A. L. & Mukhtar, H. Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent -epigallocatechin-3-gallate in androgen-sensitive androgen-insensitivetive human prostate carcinoma cells.
This study aims to explore the substitution effect of 3-OH in flavonols on the in vitro anti-proliferative potency against both androgen-sensitive and androgen-insensitive human prostate cancer cell lines.
The 4T1 orthotopic model closely mimics the progressive forms of estrogen-insensitive human metastatic breast cancer [ 16].
Both compounds have been reported to increase the proliferation of prostate epithelial and estrogen-sensitive human breast cancer (MCF-7) cells, but not of estrogen-insensitive human breast cancer (MDA-MB-231) cells [ 20– 20].
