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These testosterone insensitive cells can then lead to Androgen-Independent Prostate Cancer (AIPC) [6].
Have the authors investigated whether MELK knockdown in these insensitive cells affect their cell cycle distribution?
BSO treatment increased apoptosis induction both in sensitive and insensitive cells.
The effect on cell proliferation was stronger in androgen insensitive cells.
Do the insensitive cells have another protein that inhibits p53 other than MDM2 that is lost in sensitive cells?
In this case cells that are sensitive to sphingoid base-induced growth arrest will die and insensitive cells will survive.
Similar(40)
Since not all ASCL1-high/NEUROD1-low cell lines are sensitive to NB-598, we also included an insensitive cell line (H2081) from this category to more accurately represent the diversity of SCLC cell lines.
Furthermore, growth inhibition against gefitinib insensitive cell lines PC9-GR4 (Del19/tested were tested, compounds 6f and 7e showed about eight and three folds respectively greater potency than gefitinib.
Similarly, in the O2 insensitive cell lines (HeyA8 and SKOV3) the proportion of mitotic cells remained unaltered regardless of O2 concentrations (Figure 3).
This is expected because, as noted previously (Table 1), the proportion of cells at G2 in the O2 insensitive cell lines were also unaffected by O2 concentration.
Thus far we have demonstrated that O2 sensitive cell cycle response at the G2/M transition is lacking in the O2 insensitive cell lines.
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