The upstream regulators Dachsous and Fat and the downstream effector Yorkie, and its transcriptional partners, must have evolved to integrate multiple inputs and to activate different targets.
Three biochemical markers: lactate, norepinephrine and glucose were applied as input signals to activate the enzyme logic system.
Though it has the same effect as the original, the user does not need to input chakra to activate, thus injuries are automatically regenerated as the damages are done.
The study of corticostriatal projections has primarily concentrated on the focal projections due to the relatively large, coordinated input required to activate the medium spiny neurons (Wilson, 2004).
Indeed, all three inputs to MSN4 activate it.
If any of the positive inputs is sufficient to activate expression (A1 ∨ A2) and the activity of the inhibitory input is sufficient to inhibit expression of the target gene, the Boolean expression for the activity of G reads (4) For the ODE model, we used kinetics as simple as possible.
Fig. 3A shows that the device behaves as expected, with clear digital-like logic AND characteristics: the sensor output is high only when both arsenic and mercury are above a certain threshold, similar to that of the single input sensors, sufficient to activate the two inputs of the genetic AND gate.
Specifically, we desired the capsid to require two different protease inputs in order to activate the virus, similar to how a digital AND gate operates.
This activation occurred before the presentation of the sound, i.e. the mere expectation of an auditory input was found to activate the auditory cortex.
A fundamental technical hurdle in systems neurophysiology has been to record the activity of individual neurons in situ while using microstimulation to activate inputs or outputs.
