Probabilistic simulations were carried out to account for the effect of uncertainty regarding the model inputs on cost-effectiveness.
Probabilistic simulations were undertaken to account for the effect of uncertainty in the model inputs on cost-effectiveness; 20,000 simulations were performed, simultaneously varying the following parameters for all four procedures: procedural death, recurrence rates, complications rates, quality of life and treatment cost.
The school board and the administrators have tried to be sensitive to the entire community, being available for public input on costs and educational matters, discussing numerous alternatives, communicating through television and newsletters and holding environmental and public hearings.
The financial and non-financial incentives attached to the results will also vary, both in their absolute amounts and their potential importance to the recipient organizations, depending on other sources of available financing, on the availability of other inputs, on the cost of doing business and relative pay of health workers.
Finally, we examined the effect of variations in important inputs on the cost-effectiveness of IPC in all 70 countries grouped in order of cost-effectiveness.
In order to explore the combined impact of all uncertainties in the model inputs on the cost-effectiveness, a probabilistic sensitivity analysis (PSA) was conducted.
We assessed a) the impact of changes in underlying analytical choices (such as whether to discount health gains or not), b) the influence of specific input parameters on costs and effects (such as drug prices and disability weights), and c) the potential variability around total costs and effects of different interventions.
The Treatment Inventory of Costs in Psychiatric patients (TiC-P) will be applied to collect input data on costs.
To estimate 2012 treatment costs for each of the regimens, model inputs on the pharmaceutical cost of bendamustine, alemtuzumab, chlorambucil, the required premedications and concomitant medications, and subsequent treatments were obtained from the Centers for Medicaid and Medicare Services hospital outpatient file and Red Book.
Figures are United States dollars, year 2005 (Tsh.1205 = US$1) Table 5 shows the results of sensitivity analyses testing the impact of varying key inputs on the economic costs in the program.
The increasing demand for economic evaluation of health care interventions has lead to a corresponding rise in the derived demand for evidence on the key parameter inputs into cost effectiveness models.
