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In particular, we find that the symmetry of the CCF distinguishes in general, but not always, the case of shared inputs between two neurons from the case in which they are directly synaptically connected.
Reviewer #2: The study by Sakuri and coworkers reports a novel finding: the sensitivity of a neural network to injury depends on the relative weight of opposing synaptic inputs between two component neurons in spatially separated areas.
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To explore the consequences of this asymmetry, we extended the above network to study development when high rate inputs alternate between two locations.
It seemed possible that the effect of ME on the remaining RGC axons was mediated by the imbalance of visual inputs between the two eyes.
This result suggests that the imbalance of visual inputs between the two eyes is not sufficient for changing RGC projection patterns in the mouse dLGN after eye-specific segregation is mostly complete.
Because monocular deprivation (MD) results in the imbalance of visual inputs between the two eyes and is known to trigger alterations in the morphology of RGC axons in cats and primates [41], [42], we performed MD by unilateral eyelid suture at P10, which is before natural eye-opening.
In the one-handers studied here, who rarely experience phantom sensations (Price, 2006), the observed reduction in inter-hemispheric connectivity may instead be related to the strong and chronic lateralisation of motor behaviour, resulting in dis-synchronisation of inputs between the two hand regions, as will be discussed below.
The network then transitions, with increasing external input strength, between two regimes: (1) For weak activation, the network is very weakly coupled, with neuronal input dominated by external input (from outside the network) rather than network input.
This is because the rounding of a slightly wavering input value between two output values has a more dramatic effect when those output values are farther apart.
We thus use this as the stop criterion and terminate the estimation process when the difference of estimated input SNRs between two iterations is less than 0.5 dB.
The design is of a cascade Y-branch waveguide structure that equally distributes the input power between four output waveguides.
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CEO of Professional Science Editing for Scientists @ prosciediting.com