Studies with HSV-1 mutants lacking a functional TK gene have shown that neurones containing high latent viral DNA loads could still be achieved even in the absence of TK, demonstrating that neurons in vivo have the potential to survive very high viral inputs transported from peripheral sites (Thompson & Sawtell, 2000; Wakim et al., 2008).
Because of this reasoning, I would suggest to move the sections " Membrane-located metabolism and enzyme-like transporters" and " An important input from transport studies" to the next chapter ("Towards a new membrane model").
Sections " Membrane-located metabolism and enzyme-like transporters" and " An important input from transport studies" : It should be noted that some results directly related to the membrane structure, apparently, were not recognized by the community right away because their authors were interested in quite different subjects and therefore did not put emphasis on these results.
The Location Analysis Model for Belgian Intermodal Terminals (LAMBIT) is based on three main inputs: transportation networks (GIS), transport prices and container flows from the municipalities to and from the port of Antwerp.
On the other hand, mobile phone data, where spatio-temporal trajectories of millions of users are passively recorded has recently emerged as a promising input for transport analyses.
In this paper a diffusion-sorption model is presented, which takes into account atmospheric input rates, transport down the soil column and radioactive decay of 7Be.
"This plan has been developed by one of the country's top traffic experts, who have successfully designed and managed plans like this many times, and they have taken input from Transport Scotland, BEAR Scotland, PKC Highways and Police Scotland".
There have been some attempts at controlling Prosopis through utilization, but they had no noticeable impacts on invasions, and these initiatives failed as input and transport costs were too high and financial returns were low (Zimmermann et al. 2006).
The main effect of the changing energy environment on the health of populations may be via worldwide slowdowns in economic growth and employment [ 12]; others have warned of growing food insecurity as globalized food production systems are disrupted by rising input and transport costs [ 32].
While NPC-mediated gating does not require an energy input, nucleocytoplasmic transport and the accumulation of cargoes in the nucleus and cytoplasm are driven by the formation and maintenance of concentration gradients across the NE by GTPases and ATPases in the nucleoplasm and cytoplasm (reviewed in Rout et al. 2003; Strambio-de-Castillia et al. 2010).
