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A limitation of the study may be that the small sample size allowed participant's input to be obtained from only three clinical sites, although they were located in separate regions of the country.
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In particular, the existing software reviewed in the "Background" section, accept gene lists as an input (lists are to be obtained through different dedicated tools), so they cannot represent and analyze the gene expression level changing along the chromosome.
This instrument allows the Bode diagram of any network or electronic circuit with an input and an output to be obtained, even though this implementation was not previously known.
In this study, the input function was assumed to be obtained by an arterial blood sampling, which is challenging in practice.
Although tracer kinetic analysis of DCE-MRI data results in the estimation of physiologically relevant parameters, the requirement for high-temporal resolution data – enabling an arterial input function (Parker et al, 2006) to be obtained – and pre-contrast T1 measurements make DCE-MRI studies difficult to implement.
Again, the response of the EGFR and GPCR models to this sinusoidal input can be obtained by finding the inverse Laplace transform of the product G(s) f s), where G(s) is the corresponding transfer function.
The input to PTMClust is obtained using a blind PTM search method [e.g. SIMS or InsPecT Tanner et al. (2005)].
Alternatively, modulated visual input can be obtained in the feedback from the amygdala to the inferior occipital gyrus.
All adaptational or gain control mechanisms face the challenge of obtaining a reliable estimate of the property of the input to be adapted to and obtaining this estimate sufficiently rapidly to be useful.
This input can be obtained by physical scale modelling.
Furthermore, Sobol's sensitivity indices to identify influential random inputs can be obtained directly from the surrogated gPC model, which in turn further reduces the required simulations remarkably.
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