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The satisfactory correspondence provides confidence in the analytical modelling procedure.
In order to provide confidence measures in such cases, the p value of the gGCSI is obtained by repeatedly calculating the gGCSI using randomly shuffled input GC skew data series.
Organizational inputs were direct inputs provided by BRAC.
The model predicts RLM stability (with 82% accuracy and a kappa value of 0.65 for test data set) based solely on chemical structural inputs, and provides a clear assessment of confidence in the prediction.
To incorporate the uncertainty of input values into our estimates, we performed Monte Carlo simulations and sensitivity analyses, providing 95% confidence bounds for all of the estimates.
To provide more confidence in the obtained scores, we not only restricted the input parameters of the hypergeometric distributions (see Hypergeometric distribution) but also used a second method.
This is particularly relevant for PBPK models as predicted concentrations at the site of action can be used as input into PK-PD models, although such applications may need to be validated with preclinical tissue data to provide more confidence.
The closer the new input data provided to the ANN are to the data that were used for development of the ANN, the higher the confidence in the prediction.
"It will provide some confidence.
Do you think widening input would provide valuable insight?
Consulted: Provides input and advice (two-way communication).
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