As expected kLa depends on power input per liquid volume.
With increase of electrical energy input the liquid emanation from press-cake was intensified up to some level of expression, which seems to correspond to the destruction of quasi totality of cells.
However, in case of the foam stirrer a higher power input per liquid volume is needed in order to achieve the minimum stirrer speed required for complete dispersion of the gas.
The output of UniSelect can be used directly as an input for liquid handling robots to complete the cycle from sequence data collection back to reaction setup, without the need for human intervention.
The performance of these three reactors, typical of the fine chemicals, bioprocessing and pharmaceutical process industries was evaluated and compared in terms of geometry/size, gas flows, power inputs, pressure, liquid mixing, oxygen mass transfer, reaction speed and spatial variability of behaviour.
At low liquid input conditions both the liquid input and bubble size had an influence on the distribution parameter.
Processing parameters analysed included concentration of coating material, liquid input rate, duration of spraying, atomisation air pressure, gun-to-surface distance and air cap setting.
Performance of a continuous high shear granulator and a twin screw granulator with paracetamol formulations were examined by face-centered cubic design, which focused on investigating key performance metrics, namely, granule size, porosity, flowability and particle morphology of granules as a function of essential input process parameters (liquid content, throughput and rotation speed).
Experimental results related to the performance of the impinging stream loop reactor and showing the influence of the specific power input in the liquid phase, the gas flow rate and the nozzle diameter on the volumetric mass transfer coefficient are presented and discussed.
