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We are also thankful to the reviewers for their time and intellectual input in this manuscript.

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Special thanks are extended to Drs. Patricia Tucker, Jennifer D. Irwin, and Anita Cramp for their expertise and input in preparing this manuscript; and to Ms. Olivia Martyniuk for her assistance in developing the screening forms.

The authors would like to thank Dr. Marielle Gold for her intellectual input into this manuscript and Dr. Sonemany Salinthone and Sarah Fiedler for their helpful comments in manuscript preparation.

We are grateful to Dr Kamini Mendis for her valuable comments and input in the manuscript.

IAB participated with input in the manuscript writing and analysis of the data.

SS contributed to study design and provided critical input in the manuscript.

LS and LL helped draft and provide input in the manuscript respectively.

MMK conceived the idea, supervised the study and gave intellectual input in the manuscript.

RKS conceived the idea, collected the data, and gave input in the manuscript drafting.

In addition, the authors acknowledge Harshith Bhat for manuscript writing, Julia Donnelly for editing the language (on behalf of GlaxoSmithKline) and Geetha Subramanyam and Manjula K for manuscript coordination and in providing technical inputs in preparing this manuscript (all employed by the GlaxoSmithKline group of companies).

FGK is the collaborator from the Medical College and provided the clinical inputs in the manuscript.

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