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The minimal number of input hits (default value is 2).
The supporting MDBs and number of input hits are reported.
In these significant "input hits" from all four barcoded input DNA samples, the number of overlapping nucleotides was determined.
Finally, the total number of nucleotide positions from all significant "input hits" was calculated and compared to the S. cerevisiae genome size.
The correlation of the predicted P-value {i.e. the minimal P-value that was reported from any of the MDBs that support such prediction, transformed to [1-log P-value)]} with the fraction of MDBs or the input hits is quite significant (R = 0.496 and R2 = 0.419, respectively).
The miRIS balances between the consistency of prediction among the selected MDBs and the fraction of hits from the total size of the input, with an equal contribution of these two components: The fit between the number of MDBs that support the predictions and the ratio of the input hits from the input size is moderate (R2 = 0.305).
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An experimentally validated complex of Dengue NS5 and compound 27 (6LS) were used as pharmacophoric input and hits were identified.
Similar criteria were applied to filter barcoded input DNA hits.
Higher input costs hit all manufacturers alike, so they all wanted higher prices.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com