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However, major limitations of these models include the use of very high input doses of virus, routes of inoculation that do not mimic natural infection and the use of mouse-adapted strains of virus.
The model embodies important information about the pharmacokinetics of each enantiomer in neonates, from which changes in the concentration time profile can be examined and re-examined when input doses or regimens change.
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In Equation 4, the terms designated with lowercase letters represent the input dosing and tumor response data for each group of dosed animals or controls.
Our interest in this type of signaling is due to the findings in the literature that in many biological signaling systems, oscillations or rhythmic pulses can be more efficient in evoking responses than the same input dose given at a constant level [86].
As expected, the amount of DARPin 57.2 binding to primary CD4+ cells was dependent on the input dose (Figure 1E).
The level of staining was dependent on the input dose of DARPin 57.2, as seen in our in vitro binding studies (Figure 1E).
It was shown that signaling dynamics mediates transfer of input dose information (Selimkhanov et al., 2014).
Radioisotope levels were measured by a gamma counter and expressed as percentage of the input dose (Cpma).
The above experiments were all performed with a single dose of L. monocytogenes but it is possible that growth rates and ceilings are dependent on input dose.
The input dose was determined by measuring two 100- μl aliquots of PBS containing [I]iododeoxyuridine-labelled tumour cells in parallel with the liver samples (100%).
In theory, the used input dose of approximately 2 × 10 PFU could have been too low to give rise to detectable viremia.
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