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The HSTM designs that Garakabu2 takes as input are those developed using an industrial-strength model-based development environment ZIPC.

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The estimated gene trees used as input were those derived from single locus tree reconstructions (Additional file 3) and branch lengths as estimated in BEAST.

The estimation results obtained using an optimal input are compared with those obtained with an input optimized in a more classical context (Gaussian measurement noise and parameters a priori known to belong to some boxes).

Observations made on numerical study also indicate that estimation results obtained from a band-limited white-noise input are more accurate than those obtained from the periodic one.

The molecules that were added to the input list are those that increased the overall match of the input as a set and the output as a set.

In 13 of the 23 patients, BPND values derived from the supervised cluster input were systematically smaller than those using the cerebellar input.

However, some modes of the system may not influence the outputs and the residual appropriately if the input is not exciting enough for those modes.

Only patients requiring multi-disciplinary input were seen by the team – those patients requiring uni-disciplinary input (approximately two referrals per month) were forwarded to other services.

Input data costs are those related to drug acquisition, AE and complication consequences.

Note that both the dataset and the models are accessed indirectly via URIs, so the only data transferred on input and output are those URIs, not actual content.

These label inputs are representative of those commonly used in C-ILEs [ 6, 32– 32].

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