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Increased channel activity results in neural sensitization that causes hypersensitivity to sensory input and contributes to painful inflammation by a mechanism known as neurogenic inflammation.
The spontaneous activity in A fibres can trigger central sensitization in the spinal cord, which amplifies the input and contributes to neuropathic pain sensations (Michael et al., 1999; Molander et al., 1994; Noguchi et al., 1995).
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