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Increased channel activity results in neural sensitization that causes hypersensitivity to sensory input and contributes to painful inflammation by a mechanism known as neurogenic inflammation.

The spontaneous activity in A fibres can trigger central sensitization in the spinal cord, which amplifies the input and contributes to neuropathic pain sensations (Michael et al., 1999; Molander et al., 1994; Noguchi et al., 1995).

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A.M., A.S., S.B., V.S. and W.MacN. provided intellectual input and contributed to the writing of the manuscript.

LYL and ONN provided conceptual input and contributed to the final manuscript.

OB oversaw data input and contributed to the analysis and reporting.

R.B. and J.B. provided intellectual input and contributed to the manuscript.

SCC, YCC and CCH provided conceptual input and contributed to the final manuscript.

JSB provided intellectual input and contributed to study design and interpretation of results.

DS participated in study design, provided intellectual input and contributed to manuscript writing.

YPL designed the study, provided conceptual input and contributed to the final manuscript.

YPL, YHS, YCC, CCH and CJC provided conceptual input and contributed to the final manuscript.

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