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A.M., A.S., S.B., V.S. and W.MacN. provided intellectual input and contributed to the writing of the manuscript.
DS participated in study design, provided intellectual input and contributed to manuscript writing.
LYL and ONN provided conceptual input and contributed to the final manuscript.
OB oversaw data input and contributed to the analysis and reporting.
R.B. and J.B. provided intellectual input and contributed to the manuscript.
YPL designed the study, provided conceptual input and contributed to the final manuscript.
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Increased channel activity results in neural sensitization that causes hypersensitivity to sensory input and contributes to painful inflammation by a mechanism known as neurogenic inflammation.
The spontaneous activity in A fibres can trigger central sensitization in the spinal cord, which amplifies the input and contributes to neuropathic pain sensations (Michael et al., 1999; Molander et al., 1994; Noguchi et al., 1995).
LC and SS inputted and contributed to analysis of the data.
All co-authors gave expert inputs and contributed to the critical review of subsequent drafts.
BAS, DC and MJP developed the study methods, determined the model settings and inputs, and contributed scientific advice.
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