Sentence examples for inoculation model from inspiring English sources

For the s.c. inoculation model, HT1080-GFP-CEA, HT1080-GFP and MKN45-GFP cells were inoculated s.c. into the mice (1 × 10 cells in 100 μL of culture medium).

Thus, together with developing macaque models that mimic natural transplacental transmission23,25, further development and optimization of the direct fetal inoculation model presented here can address remaining key questions in ZIKV pathogenesis and provide important proof-of-concept information on the efficacy of interventions to guide clinical trials.

Coadministration of these two compounds orally for 6 mo at doses that were individually ineffective in SynTg mice and in a striatal α-synuclein preformed fibril inoculation model resulted in reduced accumulation of phosphorylated α-synuclein, preserved neuronal integrity and function, diminished neuroinflammation, and improved behavioral performance.

The low dose inoculation model should ultimately provide insights into mechanisms that are responsible for dendritic cell recruitment into leishmania lesions, mechanisms that facilitate parasite acquisition by skin dendritic cells and cellular interactions that eventuate in T cell priming and lesion involution.

The present study was designed to evaluate the effects of IL-1β on the expression of its corresponding receptor IL-1 RI, as well as on the closely related TNFα receptors TNF RI and TNF RII in airways using a mouse organ culture assay and intranasal inoculation model.

In fact, some parenting folk wisdom embraces an inoculation model, suggesting we expose children to small, controlled doses of potentially problematic experiences in the effort to better prepare them to ward off future negative outcomes on their own.

Basic research and the combination of reliable animal inoculation models, reverse genetics and computational biology tools will allow the rational design of safe and effective FMD vaccines.

Recent studies of murine cutaneous leishmaniasis in a model system in which infection is initiated with lower, more physiologic numbers of parasites confirm many of the important findings obtained in "high dose" inoculation models, but important differences have been noted.

Since the natural disease progression is altered in i.v. inoculation models [29], it is unclear how antiviral efficiency tested in i.v. models correlates with antiviral efficacy in naturally occurring human diseases.

This might be due to the lack of attention given to the role of hypogonadism in cachexia or traditional tumor inoculation models do not develop hypogonadism.

To avoid these confounding factors, we employed a re-inoculation model.