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An innovative trial design was developed including translational research and a phase I aspect.
Innovative trial designs and use of valid surrogate endpoints may expedite this process.
Innovative trial designs may be needed to expedite the clinical development of these targeted agents.
Innovative trial designs that evaluate intermittent (on demand) treatment are likely to become more common in the future.
Innovative trial design may help to screen for potentially interesting chemokine antagonists in an early stage of development.
The analysis of synovial biomarkers is increasingly used in the context of innovative trial design in rheumatoid arthritis (RA).
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Clinical trials have rarely developed standard procedures for collecting and documenting tissue, although more recent innovative trials do so [ 84].
Furthermore, the recent opportunities in terms of innovative therapeutic approaches [ 4, 5] highlight the relevance for patients and families of obtaining a correct molecular diagnosis, which is required in order to be included in innovative trials.
It is also important that researchers obtain material from sequential samples (with parallel outcome data), taken before and during treatment with conventional therapies, and from biologically directed innovative trials of targeted therapies.
An international delegation of oncology experts presented the innovative clinical trial strategies and discussed the biomarkers for cancer early detection and clinical trials, targeted therapy, and new drug development.
Brent and Melissa Stockwell recently conducted an innovative, formal trial to find out.
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