"The only large clinical trials that have been going on involve innocuous treatments, like antioxidants, low-dose aspirin, or supplements like calcium," Sachs said.
As for chelation, hyperbaric oxygen chambers, or even more innocuous treatments such as dietary supplements, Fitzpatrick calls them a "colossal waste of parental energy and a distraction.
In some circumstances common innocuous treatments—such as vitamins or over the counter analgesics—are used; in other circumstances physicians use antibiotics and sedatives as placebo treatments.
Recommending relatively innocuous treatments such as vitamins or over the counter analgesics to promote positive expectations might not raise serious concerns about detrimental effects to patients' welfare.
This exclusion is not so innocuous because treatment assignment may influence retention in clinical care and hence the availability of follow-up data.
The study investigates whether an antibiotic applied to the eye would affect bacteria in the nose and mouth as well, which might indicate that what seems to be an innocuous and limited treatment may profoundly change a wider area of the body and foster resistant microbes.
Efficient and specific intravitreal transduction of Müller cells by this vector will permit the development of more innocuous and effective treatments for retinal degenerative conditions through panretinal secretion of neuroprotective or anti-angiogenic factors, as well as new approaches to investigate fundamental questions in the biological role of this cell type in the retina.
Messi, who is due to captain Argentina at this summer's Copa America in the US, was caught up in a seemingly innocuous challenge and, after treatment, headed straight to the dressing room.
Injection-site reaction and floaters were reported in almost all cases but were innocuous and resolved without treatment.
