If this cytoplasmic enzyme is the terminal S° reductase, it is likely to be peripherally associated with the inner membrane and oriented so that sulfide, a toxic product, is immediately protonated and diffuses outward.
The majority of transplanted CrxGFP cells that integrated into the host ONL displayed the unambiguous morphology of mature rod photoreceptors including spherical synapses, a condensed nuclear heterochromatin configuration and correctly oriented inner segments (Fig. 3A D).
On the basis of scattering properties and Q structure, Cormier (2007) inferred textural differences between the eastern and western hemispheres near the surface of the inner core, including vertically oriented structures in the eastern hemisphere.
DOI: http://dx.doi.org/10.7554/eLife.00951.014 Our structure reveals that the concave surface of the inner coat heterotrimer is oriented towards the membrane and the Sec31 binding site towards the coat exterior, as previously predicted (Bi et al., 2002).
For whole-cell recordings, the perfusion system consisted of solution reservoirs, manual switching valves, a solenoid-driven pinch valve, and two tubes (inner diameter, 0.3 mm) oriented at 90° inserted into the culture dish (modified from ref (23)).
We live in a society oriented around our inner wonderfulness.
The principal ingredient of our theory is the assumption that the water molecules in the inner Helmholtz layer are strongly oriented by the field.
As Chodorow writes, "Because they are parented by a person of the same gender … girls come to experience themselves as less differentiated than boys, as more continuous with and related to the external object world, and as differently oriented to their inner object-world as well".
The tendons are posterodorsally oriented, and the inner set more strongly so.
However, the reverse binding mode, with the carboxylate oriented towards the inner binding pocket to hydrogen bond with Ser117 and Ser117', is not unusual and has also been observed previously in TTR complexed with diclofenac (a biarylamine), several diclofenac analogues, and some diflunisal analogs [24], [25], [29].
