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Another is the likelihood of missing some databases due to unfamiliarity; this is particularly true for clinicians and researchers who are specialized in inner ear research but are not necessarily familiar with genomics and bioinformatics.
This has been one of the major challenges and roadblocks in inner ear research".
In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.
We conclude that two-photon fluorescence microscopy allows the investigation of cochlear microvessels and is potentially a valuable tool for inner ear research.
The integration of different inner-ear datasets and links to a variety of other database makes the SHIELD a useful starting point for inner ear research.
Taken together, our results support the implementation of Xenopus as a viable model for inner ear research, especially for investigation of hair cell regeneration, morphogenesis, and organogenesis.
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Lack of human RNA tissue from the inner ear: Unlike miRNA research in the cancer field, where much of the work is focused on tissues and tumours derived from human patients, research in the deafness field does not base itself on human tissue.
We expect the database will become the one-stop resource for inner ear molecular and genetic research.
Current understanding of inner ear biology stems from research that has focused on genetics, determining molecular elements required for hair cell function and regeneration, endorgan development, and identifying ototoxic factors and molecular targets for therapeutic treatments [ 5, 9].
– Liza, Connecticut A. One area of exciting research involves inner ear hair cell regeneration with the use of stem cells.
This review summarizes the main technical approaches that are viable options for in vivo manipulation of gene expression in the mature inner ear, as well as major research and clinical issues likely to benefit from such genetic manipulations.
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