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One possibility was innate variations in basal metabolism--calories burned by normal body processes such as digestion.
Indeed, two studies suggested that the likelihood of migraine attack development exhibits innate variations [86, 87] – suggesting a migraine threshold that varies over time.
Overall, our findings demonstrate strain-specific patterns of ultrasonic calls that may represent different lexicons, or innate variations in complex vocal repertoires, in genetically distinct strains of mice.
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The high dispersion in the data corresponding to the in vivo experiment is notable and probably due to the innate variation of the animal models compared to the controlled laboratory conditions of the in vitro experiments.
However, since initial body size was not manipulated, we cannot distinguish between effects of body size per se and innate variation in growth rate.
However, the small sample numbers and innate variation in p21CIP1 levels in these studies does not render such observations inconsistent with ours.
Furthermore, even though we made a strong effort to keep the ultrasound probe position consistent, the innate variation between animals and the fast injection times meant that visualisation was not always possible.
This approach, while simplistic, has several advantages: 1) it reflects the actual behavior of the data in the study, including the correlation between variables; and 2) it is simple to understand, and not dependent on statistical tests of significance which are affected by sample size and the innate variation in measurements.
For example, a previous paper on ovarian cancer found significant heterogeneity between diagnostic groups arising from innate tissue variations[ 43].
In agreement with this possibility, different strains of C. elegans exhibit innate genetic variation in their interactions with specific bacteria.
It is certainly a challenge to pick up diabetes-related processes among these other pathological processes and the innate interindividual variation in brain structure and cognitive performance.
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