NK cells are a major innate source of IFN-gamma (Travar et al., 2016; Waggoner et al., 2016).
To the extent that the Akan notion accommodates a common humanity as an innate source of value, it supports moral equality.
ILC2s are a critical innate source of type 2 cytokines, such as IL-4, IL-5, IL-9 and IL-13, which can induce eosinophilia, mastocytosis, activation of alternatively activated macrophages, goblet cell hyperplasia and muscle contractility, and tissue repair (Pulendran and Artis, 2012).
► ILC2 provide an innate source of type-2 cytokines (IL-5, IL-9 and IL-13).
Importantly, these cells provide a potent innate source of cytokines (that were previously primarily associated with T helper cells), and play diverse roles in lymphoid tissue formation, immunity, inflammation and tissue remodelling [ 1].
ILC2 on the other hand, which form the focus of this review, provide an innate source of type-2 cytokines and are critical for the initiation of anti-helminthic and allergic immune responses.
ILCs have also been shown to be a major innate source of IL-13 in allergen-challenged lungs, and to mediate IL-25-induced AHR and eosinophilia in mouse asthma (Fig. 1E) (Barlow et al., 2012).
Our study clearly demonstrates that IL-10 signaling in T cells is critical for the pathogenesis of CIA by maintaining the level of Foxp3 and consequently contributing to the dysfunction of Tregs as well as to the increased expression level of the innate source of IL-17A by γδ T cells.
