Exact(8)
NK cells are a major innate source of IFN-gamma (Travar et al., 2016; Waggoner et al., 2016).
To the extent that the Akan notion accommodates a common humanity as an innate source of value, it supports moral equality.
ILC2s are a critical innate source of type 2 cytokines, such as IL-4, IL-5, IL-9 and IL-13, which can induce eosinophilia, mastocytosis, activation of alternatively activated macrophages, goblet cell hyperplasia and muscle contractility, and tissue repair (Pulendran and Artis, 2012).
► ILC2 provide an innate source of type-2 cytokines (IL-5, IL-9 and IL-13).
Importantly, these cells provide a potent innate source of cytokines (that were previously primarily associated with T helper cells), and play diverse roles in lymphoid tissue formation, immunity, inflammation and tissue remodelling [ 1].
ILC2 on the other hand, which form the focus of this review, provide an innate source of type-2 cytokines and are critical for the initiation of anti-helminthic and allergic immune responses.
Similar(52)
These results indicate that similar gene network architecture programs innate sources of IL-17, independent of anatomical origins.
These innate sources of IL-17 play a crucial role during stress responses and mucosal host defense.
Furthermore, innate sources (macrophages, neutrophils and NK cells) of this pivotal cytokine can compensate for the loss of functional T-cells in CS-challenge models.
Thus, targeting innate cellular sources of IL-17A may offer an alternative strategy to reduce pathogenic macrophages in COPD.
Alternative innate cellular sources should be considered when developing strategies to combat excessive IL-17A signalling in chronic lung conditions.
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